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Birla Fertility & IVF
Birla Fertility & IVF

IVF Injections Side Effects

  • Published on May 09, 2022
IVF Injections Side Effects

IVF in itself can be perplexing for couples who are trying to conceive. Fertility treatments can take an emotional toll on the couple’s mind and body. Couples, when thinking about IVF, think about the possible side effects that may come along with it. Though fertility treatment is safe but it can still make the couples feel anxious.

In this article, with insights from Dr. Meenu Vashisht Ahuja, leading fertility specialist at Birla Fertility & IVF, we will explore the various side effects of IVF injections. 

Fertility experts make sure that the fertility treatment offered has no side effects and the whole treatment is as safe as possible. Below are some of the side effects that a patient might experience after injections.


Bruising and soreness

During the ovulation period, doctors inject some fertility injections to help stimulate the ovaries and to develop healthy multiple eggs. These injections are given for at least 10-12 days to help induce and stimulate the ovaries. After the injections, the patient might experience some discomfort and pain, indicating ivf side effects. For this, it is recommended that the patient receives injections in some different sites of the body to avoid pain and soreness in the same position.

Nausea and vomiting

Every woman going through the treatment wonders and stresses about what would be the side effects of ivf injections. Not every woman goes through these IVF side effects but some may experience severe vomiting and weakness after IVF injections.


Feeling bloating is a common sign and symptom a woman experiences around her menstrual cycle. The hormones in the body change, meaning the progesterone and estrogen levels in the body change, due to which the body starts to retain more water than salt. Due to water retention, the body becomes swollen, making one feel bloated. These same hormones are being used by the body to stimulate the development of eggs and are also present in the body in larger amounts during fertility treatment.

Breast Tenderness

Breast tenderness is a common symptom experienced even when the menstruation cycle is near or during the mensuration cycle. It is a side effect that many women may have experienced when on fertility medication.

Mood swings

Fertility or hormonal medication might cause mood to change. Feeling restless, irritated or feeling extremely weak every time may be an indication or a signal of IVF side effects.

Hot Flashes

Some women have reported that they have experienced noticeable hot flashes in the face, neck and chest area. They tend to become extremely hot and start to sweat due to the fertility medications. Once the flashes are eased out, the patient might start to feel chilly as the temperature of the body suddenly comes down.

Allergic reactions

Some women’s skin is very sensitive, and there are times when the body is not able to tolerate the intensity of the medication given as fertility drugs are strong medications. They may feel itchy and redness on the injection sites.


Feeling tired and fatigued is one of the common side effects of IVF injections. This could be due to the change and shift in hormones caused by the fertility medication.

Ovarian Hyperstimulation Syndrome (OHSS)

OHSS is a syndrome that may occur in women as a side effect due to the medication given to stimulate the development of eggs in the ovaries. It causes the ovaries to be sore, causes pain, make the abdominal area bloated, and causes nausea, and weight gain.


How many injections are given IVF treatment & what are the side effects of IVF injections



Clomid is a medication given for the treatment of infertility in women. Clomid medication is given to stimulate the number of hormones that support the growth and help release eggs during ovulation. 

Clomid - Side effects & risks in image and text format

Side effects & risks of Clomid

  • Hot flashes
  • Bloating
  • Headache
  • Vaginal dryness
  • Mood swings
  • Fatigue
  • Weight gain
  • Breast tenderness 
  • Abnormal spotting



Letrozole is a drug intended to treat breast cancer but the functioning of letrozole is similar to that of Clomid, which helps in blocking estrogen receptors.  There might be cases in which the women who are not responding well to Clomid may respond well to letrozole.

Letrozole - Side effects & risks in image and text format

Side effects & risks of Letrozole

  • Fatigue
  • Dizziness
  • Headache
  • Bloating/abdominal discomfort
  • Hot flashes
  • Breast pain
  • Difficulty sleeping
  • Blurred vision
  • Abnormal bleeding/spotting



Gonadotropins is a fertility drug used for growth and sexual development. Injections are given when the menstruation cycle begins to help induce eggs in large amounts.

Gonadotropins - Side effects & risks in image and text format 

Side effects & risks

  • Headaches
  • Mood swings
  • Bloating
  • Acne
  • Dizziness
  • Upper respiratory tract infection
  • Soreness and redness
  • Nausea



Lupron is a medicine used to stimulate the ovaries. Gonadotropins contain follicle-stimulating hormone and luteinizing hormone (LH). Decreased estrogen levels are responsible for side effects from Lupron.

Lupron - Side effects & risks in image and text format

Side effects & risks

  • Headache
  • Acne
  • Stomach infection
  • Hot flashes
  • Vaginal dryness
  • Weight gain
  • Joint pain
  • Dizziness
  • Decreased sexual drive
  • Soreness

If anyone is worried about what are the side effects of IVF injections or how their body would react to the fertility injections, it is recommended to visit an IVF expert for clearing their doubts. Consult with Dr. Meenu Vashisht Ahuja  for further information.


Role of Fertility Drugs During In Vitro Fertilization (IVF)

Recommended fertility drugs are necessary during In Vitro Fertilization (IVF) procedure. The key role of fertility drugs is to balance the level of hormones and stimulate them to produce viable eggs. The formation of the right amount of eggs triggers ovulation which helps increase the chances of conception.

The fertility complications may vary from one person to another. Thus, the expert may prescribe fertility drugs orally or through injections depending on the severity. Fertility drugs taken through injections have much more noticeable side effects compared to oral ones.



Can IVF damage your body?

Every woman’s body is different, and how the IVF treatment will affect her body differs. Visiting the right clinic and undergoing the right diagnosis can help minimise the possible damage or side effects.


How painful are IVF injections?

IVF injections do not cause much pain, the patient might feel slight discomfort or a stinging sensation. The needles injected are way too thin to cause any pain. 


Does IVF work the first time?

The chances of IVF working the first time are dicey as it depends on the diagnosis and treatment. 


How many days do you take IVF injections?

For the IVF cycle, the medication is given for at least 10-12 days to boost the follicles in the ovaries to help produce more eggs.

Written by:
Dr Meenu Vashisht Ahuja

Dr Meenu Vashisht Ahuja

Dr Meenu Vashisht Ahuja is a prominent gynaecologist and fertility specialist with 17+ years of training and work experience across India. She has extensive experience in the field of infertility and IVF and has been associated with the best IVF centers in Delhi. Currently, she is working as a visiting consultant specialist at multiple fertility centers across Delhi.   

Over 17+ years of experience

Lajpat Nagar, New Delhi

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