Preimplantation Genetic Screening (PGS)
Preimplantation Genetic Screening
at Birla Fertility & IVF
Preimplantation Genetic Screening or PGS is a state-of-the-art diagnostic technique which is performed at a very early stage of embryo development in an IVF or IVF-ICSI cycle to screen their chromosomal make-up. This helps to identify and transfer embryos with a low risk of chromosomal abnormalities and increase pregnancy rate as well as lower the risk of miscarriage in certain situations.
At Birla Fertility & IVF we offer Preimplantation Genetic Screening (PGS), Preimplantation Genetic Diagnosis (PGD) as well as a comprehensive genetic panel for both men and women trying to become pregnant.
Why Get Preimplantation Genetic Screening
Preimplantation Genetic Screening is recommended in an IVF or IVF-ICSI cycle in the following situations:
If the female partner is aged over 37 years of age
If either the male or female partner has a family history chromosome problems
In case of recurrent IVF failures without an obvious cause
In case of recurrent miscarriages
The Preimplantation Genetic Screening Process
In this procedure, the embryologist carefully removes one or more cells from each embryo and counts the number of chromosomes in these cells in a process called “Next Generation Sequencing”. This test is generally carried out once the embryo is in the blastocyst stage (day 5 or day 6 of the embryo culture). Blastocysts have two distinct layers of cells of which the inner cell mass eventually forms the baby. Sample cells for the screening are biopsied from the outer layer which develops into the placenta. Biopsied embryos are frozen and stored till the completion of the tests. Once the result of the test is known, healthy embryos with no apparent chromosomal abnormalities are selected and prepared for transfer.
Frequently Asked Questions
Why is PGS recommended for older women
The risk of having chromosomal abnormalities in eggs and embryos increases steeply after the age of 35 years in women. This increases the risk of implantation failures, miscarriages as well as congenital abnormalities in the baby. PGS can help in lowering these risks.
What are the risks of PGS?
PGS involves collecting cells from the embryo. This can damage or destroy the embryo. However, advances in the field of assisted reproductive technology and embryology have significantly improved survival rates for embryos through PGS. In some cases, all embryos may be found with chromosomal issues resulting in a cancelled IVF cycle.
What are the benefits of PGS?
In certain situations, PGS can help in reducing the risk of implantation failure as well as risk of miscarriages as it allows the selection of the healthiest embryos for transfer. It also increases the chance of having a healthy baby and enables better diagnostic decisions.
How many chromosomes are present in an embryo?
A healthy embryo has 22 pairs of chromosomes and 2 sex (gender) chromosomes. Incorrect number of chromosomes or chromosome aneuploidy is known to be a major cause of IVF failures and miscarriages. In rare cases, if the pregnancy is carried to term, it can lead to congenital issues in the child.
We got in touch with Birla Fertility & IVF when we decided to have a family. After discussing all our concerns, the doctor suggested preimplantation genetic screening. The process was all smooth and went well. I continued with the IVF treatment. Just in the eight months of starting the treatment, I tested positive on my pregnancy test. Amazing services!
I am happy to share my experience with the Birla Fertility & IVF team. All the team members were highly knowledgeable, well trained, professional, and helpful. I communicate with the team about my anxiety, and they treat me like a family member. Thanks to the whole team, great job!
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