Preimplantation Genetic Diagnosis (PGD)
Preimplantation Genetic Diagnosis at
Birla Fertility & IVF
Sometimes, babies can be born with a genetic condition inherited from either parent. With advances in the field of fertility medicine, detecting an inherited disease before pregnancy is becoming a more precise science. Preimplantation genetic diagnosis (PGD) is a treatment that allows us to check the genes or chromosomes of the embryo for a specific genetic condition and reduce the risk of passing it on to the baby. Approximately 600 genetic conditions can be detected through PGD. This treatment is also known as preimplantation genetic testing for monogenetic disease and offers a valuable alternative to more invasive conventional prenatal diagnosis.
At Birla Fertility & IVF, we offer a comprehensive range of genetic testing including preimplantation genetic diagnosis and preimplantation genetic screening for optimal results.
Why Take PGD?
PGD is recommended for patients with:
A history of miscarriages caused by a serious genetic condition
If the couple already has a child with a genetic condition and there is a need to reduce this risk
If either partner has a family history of genetic conditions or chromosome problems
If either partner has genetic conditions like thalassaemia, sickle cell disease, cystic fibrosis and inheritable cancer pre-dispositions that are tested through PGD
The Preimplantation Genetic Diagnosis Process
In this procedure, embryos formed in an IVF or IVF-ICSI cycle are cultured for five to six days till they have two distinct layers of cells. At this stage, they are called blastocyst. The embryologist carefully removes a few cells from the outer layer of the blastocyst (biopsy). The cells are tested for the relevant
genetic condition or chromosomal rearrangement using a test which is developed specially for the couple. Biopsied embryos are frozen and stored till the completion of the tests. Once the result of the test is known, the healthiest blastocysts are prepared for transfer.
Frequently Asked Questions
What diseases can PGD detect?
Preimplantation genetic diagnosis can detect the risk of approximately 600 genetic diseases including thalassaemia, sickle cell disease, cystic fibrosis, certain inherited cancers, Huntingdon’s disease, muscular dystrophies, and fragile-X. These tests have to be designed specially for each couple.
Can PGD help in identifying the gender of the embryo?
Gender determination is illegal in India and not done with PGD.
Can babies born after PGD have any health or developmental problems?
There is no evidence that suggests babies born after PGD are at the risk of having congenital problems or developmental issues.
What are the risks of PGD?
PGD involves collecting cells from the embryo. This can damage or destroy the embryo. However, advances in the field of assisted reproductive technology and embryology have significantly improved survival rates for embryos through PGD. In rare cases, PGD may be unsuccessful in detecting the issue or give incorrect results.
I acknowledge the whole team of Birla Fertility & IVF for their kind nature and expert advice. At the hospital, I got their support throughout the IVF procedure. Our family has a genetic disease history, so we don’t want our baby to have the same. When we asked our doctor regarding this, she suggested a preimplantation genetic diagnosis. The whole team was very kind enough to provide us with in-depth information regarding the process. Thanks, doctors and staff members, for the incredible support.
I am happy with the services they provided us. I approached the Birla Fertility & IVF for IVF treatment services. The hospital has world-class IVF services with affordable pricing. The doctors’ team, the staff, and other people were very supportive throughout the process.
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