A Guide to Endometrial Receptivity Analysis (ERA)

Endometrial Receptivity Analysis (ERA)

Endometrial Receptivity Analysis (ERA) is a diagnostic test designed to determine the optimal timing for embryo transfer during in vitro fertilisation (IVF) treatment. By evaluating endometrial receptivity, ERA aims to enhance the likelihood of successful implantation and pregnancy.

What is ERA?
Why is ERA Recommended?
How ERA is Done?
Benefits of ERA Test
FAQ'S

What is ERA?

ERA is a genomic test that analyses the endometrial lining to determine the best time for embryo transfer. This test evaluates the expression of genes associated with endometrial receptivity.

ERA is performed to identify the precise window of implantation (WOI), which varies among women. Knowing this optimal time helps schedule embryo transfers more effectively.

Advantages:

- ERA improves the success rates of IVF by ensuring embryos are transferred at the most receptive time.
- This reduces the chances of implantation failure and increases the likelihood of a successful pregnancy.
- It can be helpful for patients with recurrent implantation failure (RIF) who have experienced repeated unsuccessful IVF cycles.

Why is ERA Recommended?

Here are the key reasons why ERA testing is recommended:

IVF Cycle Failure
- ERA helps identify the optimal time for embryo transfer in women who have experienced IVF cycle failures.
- By pinpointing the exact window of implantation, ERA can significantly enhance the chances of a successful pregnancy.
Recurrent Pregnancy Loss
- For women with recurrent pregnancy loss, ERA provides valuable insights into endometrial receptivity.
- This information helps in adjusting the timing of embryo transfer to improve implantation success and reduce the risk of miscarriage.
Patients with Limited Embryos
- For women with very few embryos available for transfer, ERA can help identify the optimal timing.
- This maximises the chances of success by ensuring that the embryos are transferred at the most receptive time.

How ERA is Done?

ERA evaluates uterine receptivity for embryo implantation during IVF. Here’s how ERA is performed:

ERA Test

The ERA test involves these steps:

The patient takes medications to stimulate uterine lining growth, monitored via ultrasounds and blood tests.
When adequately developed, a minor endometrial biopsy collects a small sample of uterine tissue.
The sample is sent to a lab, where 236 genes related to endometrial receptivity are analysed using advanced genetic sequencing.
The results indicate if the endometrium is “receptive” (ready for embryo transfer) or “non-receptive” (not in the optimal implantation window).

Why Choose Us

Choosing the right fertility clinic is crucial for starting your family. At Birla Fertility & IVF, we offer personalised care with expert specialists guiding you every step of the way. Our advanced labs and outstanding success rates have helped over 2,30,000 patients achieve their dream of parenthood.

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Our Doctors

Gurgaon – Sector 14, Haryana

Dr. Prachi Benara

MBBS (Gold Medalist), MS (OBG), DNB (OBG) PG Diploma in Reproductive and Sexual health

Years of experience: 16+

Number of cycles: 3000+

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Kolkata , West Bengal

Dr. Souren Bhattacharjee

MBBS, DGO, FRCOG (London)

Years of experience: 34+

Number of cycles: 10,000+

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Kolkata, West Bengal

Dr. Swati Mishra

MBBS, MS (Obstetrics & Gynaecology)

Years of experience: 20+

Number of cycles: 3500+

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Lajpat Nagar, Delhi

Dr. Muskaan Chhabra

MBBS, MS (Obstetrics & Gynaecology) DNB (Obstetrics & Gynecology), Infertility Specialist

Years of experience: 13+

Number of cycles: 700+

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Dwarka, Delhi

Dr. Shilpa Singhal

MBBS, M.S., Diploma in Reproductive Medicine

Years of experience: 11+

Number of cycles: 700+

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Varanasi, Uttar Pradesh

Dr. Deepika Mishra

MBBS, MS (Obstetrics & Gynaecology)

Years of experience: 14+

Number of cycles: 2500+

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Benefits of ERA Test

Here are the key benefits of the Endometrial Receptivity Analysis (ERA) test:

Optimised Timing for Embryo Transfer

Personalised Window of Implantation (WOI): By identifying the specific days when the endometrium is most receptive, ERA helps schedule the embryo transfer. This timing increases the likelihood of successful implantation.
Tailored to Individual Cycles: WOI can vary among women and even from cycle to cycle in the same woman. ERA ensures that the transfer is timed perfectly for each cycle.

Reduced Implantation Failure

By identifying the exact window of implantation, ERA reduces the risk of implantation failure.
ERA improves pregnancy and implantation rates in patients with recurrent implantation failure or unsuccessful IVF cycles.
This increases IVF success rates and reduces emotional and financial strain from repeated cycles.

Personalised Fertility Treatment

ERA provides personalised fertility treatment plans based on each patient's unique endometrial profile.
This ensures embryos are transferred at optimal receptivity for maximised implantation and pregnancy success.
ERA also conducts detailed genetic assessments of endometrial receptivity, enhancing precision in treatment planning.

Frequently Asked Questions

ERA is designed to identify the optimal window for embryo implantation by analyzing the gene expression profile of the endometrial lining, increasing the chances of successful IVF treatment.

While a standard endometrial biopsy evaluates the overall health of the endometrium, ERA goes a step further by examining the molecular signature to determine the precise timing when the endometrium is most receptive to embryo implantation.

Yes, ERA is particularly beneficial for patients with recurrent implantation failures, as it helps in personalizing the timing of embryo transfer, which might be the key to a successful pregnancy in these cases.

ERA typically provides a one-time personalized window of implantation, which remains consistent across cycles. However, if there are significant changes in the patient’s condition or treatment protocol, a repeat test might be considered.

While ERA significantly improves the chances of successful implantation by optimizing timing, it does not guarantee pregnancy, as other factors like embryo quality and overall health also play critical roles.

Endometrial Receptivity Analysis (ERA)

What is ERA?

Why is ERA Recommended?