Fertility Files – Real Cases of Infertility Challenges

When the Right Embryo Met the Right Timing

Good-quality embryos. A failed transfer. And no clear reason why implantation wasn’t happening. After 6 years of trying, the biggest question wasn’t can IVF work—it was why isn’t it working yet? Because sometimes, success in IVF isn’t about creating embryos. It’s about choosing the right ones and transferring them at the right time.

- Birla Fertility & IVF, Lajpat Nagar, (Dr. Muskaan Chhabra)

Case Snapshot

Patient AgeNot specified

ChallengesRecurrent implantation failure, possible chromosomal abnormalities, endometrial timing mismatch, hypothyroidism

TreatmentIVF with blastocyst culture, PGT-A, ERA, hormonal optimisation, personalised frozen embryo transfer

OutcomeSuccessful twin pregnancy (ongoing)

Timeline~6–9 months

Journey Timeline

1. Complex Challenges

2. Personalised Plans

3. Safe Complex & Transfer

4. Guided Transfer

5. Successful Pregnancy

The Barriers They Faced

Recurrent Implantation Failure (RIF)

No success despite transferring good-quality embryos.

Hidden Embryo Factors

Possibility of chromosomal abnormalities.

Endometrial Timing Mismatch

Uterus not aligned with embryo transfer timing.

Thyroid Imbalance

Needed optimisation for better implantation outcomes.

Unexplained Failure

Required deeper diagnostic evaluation.

Doctor's Quote

“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”

— Dr. Muskaan Chhabra

The Treatment Plan that made the Difference

IVF & Embryo Development

Controlled ovarian stimulation and ovum pick-up were performed, followed by blastocyst culture. A total of 5 blastocysts were successfully developed.

First Embryo Transfer

Two blastocysts were transferred in the first attempt. However, the cycle resulted in implantation failure.

Personalised Evaluation

The remaining embryos underwent PGT-A testing, which helped identify chromosomally normal (euploid) embryos. ERA testing also revealed a shifted implantation window, while thyroid levels were optimized before the next transfer.

Personalised Frozen Embryo Transfer (FET)

A personalised FET cycle was planned with transfer timing aligned to ERA findings, and 2 euploid blastocysts were selected for transfer.

A Story of Timing, Not Just Trying

This case shows that repeated IVF failure is often not about chance it’s about missed alignment. Even high-quality embryos may fail if: – They are not genetically normal – The uterus is not receptive at the time of transfer By combining: – PGT-A (to select the right embryo) – ERA (to find the right timing) – Hormonal optimisation (to create the right environment) A previously unsuccessful journey turned into a successful twin pregnancy. At Birla Fertility & IVF, this personalised approach helped answer the “why” behind failure and transform it into a new beginning.

The Outcome

β-hCG confirmed a positive pregnancy.

Ultrasound revealed a viable twin intrauterine pregnancy.