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Fertility Files – Real Cases of Infertility Challenges
Successful Pregnancy Following Donor Oocyte IVF After Multiple Failed Cycles
After 8 years of infertility and several failed IUI and IVF attempts, the couple came to us seeking further treatment. At 45 years of age, the patient was facing multiple fertility challenges, including poor ovarian reserve, severe adenomyosis, recurrent implantation failure, and fluid in the endometrial cavity. With donor oocyte IVF, uterine optimization, and carefully planned embryo transfer preparation, the couple successfully achieved an ongoing healthy pregnancy.
Case Snapshot
Journey Timeline
1. Complex Challenges
2. Personalised Plans
3. Safe Retireval & Transfer
4. Guided Transfer
5. Successful Pregnancy
The Barriers They Faced
Advanced Maternal Age
Age-related decline significantly affected ovarian reserve and egg quality.
Severely Diminished Ovarian Reserve
Very low AMH levels limited the possibility of success using self-oocytes.
Severe Adenomyosis
The condition affected endometrial receptivity and implantation potential.
Endometrial Cavity Fluid
Presence of intrauterine fluid further complicated embryo implantation.
Repeated Treatment Failures
The patient had already undergone 3 failed IUI cycles and 2 failed frozen embryo transfer cycles.
Emotional & Medical Challenges
Long-standing infertility along with hypothyroidism and depression added complexity to overall treatment management.
Doctor's Quote
“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”— Dr. Manjunath CS
The Treatment Plan that made the Difference
Counselling & Donor Oocyte IVF Planning
The couple received detailed counselling regarding embryo pooling with PGT-A versus donor oocyte IVF. Considering the severely diminished ovarian reserve, the couple opted for the donor oocyte IVF program. A suitable donor was selected, resulting in 5 good-quality blastocysts.
Surgical Uterine Optimization
To improve implantation conditions, uterine optimization procedures were performed, including: Diagnostic hysteroscopy with adenomyomectomy Bilateral tubal clipping Endometrial biopsy for histopathological evaluation (HPE) The HPE report was normal.
Hormonal Suppression Therapy
Post-surgery, hormonal suppression was initiated using monthly Leuprolide depot 3.75 mg IM injections for 3 months.
Endometrial Preparation & Frozen Embryo Transfer
An HRT cycle was started 21 days after the final depot dose. A triple-line endometrium measuring 8.6 mm was achieved on Day 11. Two good-quality blastocysts were transferred.
The Outcome Highlight
The IVF cycle succeeded. <span className="text-white"> She conceived.</span>
It was not an easy pregnancy, but with strict monitoring and coordinated antenatal care, she continued steadily toward parenthood.