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Live Birth After Recurrent Implantation Failure and Chronic Endometritis

Live Birth After Recurrent Implantation Failure and Chronic Endometritis

After 13 years of primary infertility, multiple IUI attempts and three unsuccessful IVF cycles, this couple came to Birla Fertility & IVF, Gorakhpur, after repeatedly receiving negative pregnancy results.

- Birla Fertility & IVF, Gorakhpur (Dr. Akriti Gupta)
Dr. Akriti Gupta

Case Snapshot

Patient Age Female: 33 years | Male: 38 years
Challenges13 years of primary infertility, recurrent implantation failure, endometrial polyp, chronic endometritis and multiple failed fertility treatments
TreatmentDonor-oocyte IVF using the husband's sperm, blastocyst culture, hysteroscopy with polypectomy, treatment of chronic endometritis, PGT-A, ERA-guided transfer planning and PRP support
OutcomeSuccessful pregnancy followed by delivery of a healthy 2.2 kg baby girl
TimelineTwo IUIs in 2016, three IVF cycles between 2021 and 2022, followed by personalised treatment at Birla Fertility & IVF

Journey Timeline

Multiple Failed Treatments

1. Multiple Failed Treatments

Uterine Evaluation

2. Uterine Evaluation

 Polyp & Endometritis Treatment

3. Polyp & Endometritis Treatment

Personalised Embryo Transfer

4. Personalised Embryo Transfer

Healthy Live Birth

5. Healthy Live Birth

The Barriers They Faced

Recurrent Implantation Failure

Despite several fertility treatments, including IVF with both own and donor gametes, pregnancy had not been achieved.

Endometrial Polyp

An endometrial polyp was identified on ultrasound and removed hysteroscopically before embryo transfer.

Chronic Endometritis

Persistent inflammation of the endometrium was subsequently confirmed and treated before proceeding with transfer.

Long Treatment History

The couple had already experienced repeated treatment failure over many years, making careful reassessment especially important.

Doctor's Quote

Doctor
“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”
— Dr. Akriti Gupta

The Treatment Plan that made the Difference

Hysteroscopy and Polypectomy

The uterine cavity was evaluated hysteroscopically and the endometrial polyp was removed before embryo transfer.

Treatment of Chronic Endometritis

The identified endometrial inflammation was managed before proceeding to the transfer stage.

Donor-Oocyte IVF and Blastocyst Culture

A donor-oocyte IVF cycle using the husband's sperm was planned, with embryos cultured to the blastocyst stage.

Embryo Assessment

PGT-A was used to provide additional information about embryo chromosome status in this selected case.

Individualised Transfer Planning

ERA findings were considered while planning transfer timing, with PRP also used as part of the personalised endometrial preparation strategy.

The Outcome

The treatment resulted in a positive pregnancy test, a confirmed clinical pregnancy and ultimately the delivery of a healthy 2.2 kg baby girl.

Outcome Background

The Outcome

A Story of Healing Before Hope

After years of unsuccessful treatment, evaluation of the uterine environment identified factors that needed to be addressed before another embryo transfer. By treating the endometrial polyp and chronic endometritis and then individualising embryo and transfer planning, the team approached the case as a combination of interconnected factors rather than another routine IVF cycle.

Every journey is unique. With science and empathy, parenthood is possible.