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Live Birth After Two Failed IVF Cycles and Severe Male-Factor Infertility
After seven years of infertility and two unsuccessful IVF cycles elsewhere, this couple visited Birla Fertility & IVF, Bhopal, for another evaluation. The female partner, aged 37, had no clearly identified female-factor cause, while the male partner, aged 42, had severe OATS, with significantly affected sperm count, motility and morphology. The treatment plan focused specifically on the male factor. Sperm were retrieved directly from the testis using TESA and then used for ICSI. Four good-quality blastocysts developed, and a subsequent embryo transfer resulted in a singleton pregnancy and healthy live birth.
Case Snapshot
Journey Timeline
1. Two Failed IVF Cycles
2. Severe Male Factor Reassessed
3. TESA + ICSI
4. Day 5 Blastocyst Transfer
5. Healthy Live Birth
The Barriers They Faced
Severe OATS
The male partner had significantly reduced sperm count, motility and normal morphology.
Previous IVF Failure
Two earlier IVF cycles had not resulted in pregnancy, making reassessment of the couple's current fertility factors important.
Long-Standing Infertility
The couple had been trying to conceive for seven years before undergoing the successful treatment.
Doctor's Quote
“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”— Dr. Sonal Chouksey
The Treatment Plan that made the Difference
TESA for Sperm Retrieval
Sperm were obtained directly from the testis to address the severe male-factor infertility.
Individualised Ovarian Stimulation
Ovarian stimulation and egg retrieval yielded 11 oocytes, of which 8 were mature and suitable for ICSI.
ICSI
The retrieved sperm were used for ICSI with the mature oocytes.
Blastocyst Development
Four good-quality blastocysts developed — two Day 5 and two Day 6 blastocysts — and were cryopreserved.
Embryo Transfer
Two Day 5 blastocysts were transferred on 5 August 2025.
A Story of Precision in Male Fertility Care
The Outcome
Ultrasound confirmed a singleton pregnancy, which progressed with regular antenatal follow-up.
This case highlights how reassessing severe male-factor infertility after previous IVF failure can help identify a more appropriate treatment pathway.