Fertility Files – Real Cases of Infertility Challenges

Beating the Odds: Dual-Factor Infertility Overcome with Precision Care

For this couple, the journey to parenthood was filled with complex challenges at every step. With both partners facing significant fertility issues, their chances initially seemed limited. She had a poor ovarian reserve, meaning fewer eggs were available. He was diagnosed with obstructive azoospermia, with no sperm visible in semen analysis. Previous attempts, including two IUI cycles with donor sperm, had also been unsuccessful. Dual-factor infertility can feel overwhelming, especially when multiple treatments fail. But with the right diagnosis, careful planning, and advanced fertility techniques, outcomes can change.

- Birla Fertility & IVF, Ahmedabad, (Dr. Nimisha Shantilal Pandya)

Case Snapshot

Patient Age Female: 28 years | Male: 31 years

ChallengesPoor ovarian reserve, obstructive azoospermia, previous failed IUI cycles

TreatmentTESA (surgical sperm retrieval), IVF with ICSI, multi-cycle approach, frozen embryo transfer

OutcomeSuccessful pregnancy and birth of two healthy baby girls

Timeline ~8–10 months

Journey Timeline

1. Complex Challenges

2. Personalised Plans

3. Safe Retireval & Transfer

4. Guided Transfer

5. Successful Pregnancy

The Barriers They Faced

Poor Ovarian Reserve

Limited egg quantity reduced chances per cycle.

Obstructive Azoospermia

Required surgical sperm retrieval (TESA).

Previous Failed Treatments

Two unsuccessful IUI cycles added emotional and clinical pressure.

Low Oocyte Yield

Every egg retrieved had to be optimally utilised.

Need for Multi-Cycle Strategy

A single cycle was unlikely to be sufficient.

Precision-Dependent Outcomes

Success depended heavily on lab expertise and timing.

Doctor's Quote

“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”

— Dr. Nimisha Shantilal Pandya

The Treatment Plan that made the Difference

Accurate Diagnosis & Planning

Identification of obstructive azoospermia enabled timely surgical sperm retrieval.

TESA & Sperm Cryopreservation

Motile sperm were successfully retrieved and frozen, allowing use across multiple cycles without repeat procedures.

Controlled Ovarian Stimulation

Carefully designed protocols ensured optimal egg retrieval despite low reserve.

Cycle 1: IVF + ICSI (Fresh TESA Sample)

7 oocytes retrieved (5 mature) 1 blastocyst (Grade 4BB) formed Frozen embryo transfer performed → Negative outcome

Cycle 2: IVF + ICSI (Frozen-Thawed TESA Sample)

4 oocytes retrieved (all mature) 2 high-quality blastocysts (Grade 4AB) formed Frozen embryo transfer performed → Positive pregnancy

Advanced Lab Techniques

ICSI was used to maximise fertilisation from limited eggs, supported by precise embryology practices.

A Story of Parenthood Against the Odds

This case highlights that even when both partners face significant fertility challenges, parenthood is still possible with the right approach. Obstructive azoospermia, when accurately diagnosed, can be effectively managed with TESA. Poor ovarian reserve does not eliminate the possibility of success, it calls for a strategic, multi-cycle approach. At Birla Fertility & IVF, this combination of clinical precision, advanced technology, and personalised care helped turn a difficult case into a successful outcome. For this couple, what once felt uncertain is now a reality, two healthy lives, and a family they had long hoped for.

The Outcome

Pregnancy was confirmed through β-hCG testing.

The patient carried the pregnancy successfully to term and delivered two healthy baby girls.