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Diminished Ovarian Reserve and Male Factor Infertility Overcome Through Personalised IVF & Microfluidics-Assisted ICSI
After an unsuccessful fertility treatment elsewhere, this couple sought answers for infertility caused by diminished ovarian reserve (DOR) and severe male factor infertility. The female partner had a low ovarian reserve with only one ovary responding to stimulation, while the male partner had high sperm DNA fragmentation (DFI 39%) and asthenoteratozoospermia. Despite the limited number of eggs retrieved, a personalised IVF strategy using microfluidics-assisted sperm selection and ICSI helped maximise every opportunity, resulting in the birth of a healthy baby.
Case Snapshot
Journey Timeline
1. Complex Challenges
2. Personalised Plans
3. Safe Retireval & Transfer
4. Guided Transfer
5. Successful Pregnancy
The Barriers They Faced
Diminished Ovarian Reserve (DOR)
A low ovarian reserve reduced the expected number of eggs that could be retrieved during IVF.
Poor Ovarian Response
Despite stimulation, only one ovary responded, limiting the number of available oocytes.
Previous Treatment Failure
The couple had already undergone an unsuccessful IUI cycle at another fertility centre.
Severe Male Factor Infertility
The male partner was diagnosed with asthenoteratozoospermia, affecting both sperm movement and morphology.
High DNA Fragmentation
A DNA Fragmentation Index (DFI) of 39% increased the risk of poor fertilisation, compromised embryo development, and reduced pregnancy potential.
Limited Embryo Availability
With only a small number of eggs available, every embryo became critically important for achieving pregnancy.
Doctor's Quote
“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”— Dr. Vineeta Kumari
The Treatment Plan that made the Difference
Personalised Minimal Stimulation Protocol
A Minimal Stimulation Protocol (MSP) was carefully planned to optimise ovarian response while considering the patient's diminished ovarian reserve and previous treatment history.
Close Monitoring of Ovarian Response
Although only one ovary responded to stimulation, the cycle was managed closely, resulting in the successful retrieval of five mature oocytes.
Microfluidics-Assisted ICSI
To overcome high sperm DNA fragmentation, microfluidics-assisted sperm selection was used before ICSI to isolate sperm with better DNA integrity and improve fertilisation potential.
Optimising Every Available Embryo
Four of the five retrieved oocytes fertilised successfully, leading to the development of a high-quality Day 5 blastocyst (Grade 4BB), which was cryopreserved.
Personalised Frozen Embryo Transfer
A carefully planned single embryo transfer (SET) was performed during a subsequent frozen embryo transfer (FET) cycle under optimised endometrial conditions.
A Story of Precision in Managing Low Ovarian Reserve and Male Factor Infertility
The Outcome
The personalised treatment approach resulted in:
Successful fertilisation of 4 out of 5 mature oocytes Development of a high-quality Day 5 blastocyst (Grade 4BB) Positive β-hCG following frozen embryo transfer Successful pregnancy Birth of a healthy baby