Fertility Files – Real Cases of Infertility Challenges

Beating the Odds: Secondary Infertility Reversal After 10 Years

A lot of couples dream of having two children, a complete family. For this couple, that dream was put on hold for nearly a decade. <br>They had experienced the joy of becoming parents once, but when they tried to conceive again, secondary infertility stood in the way. The struggle was unexpected and emotionally draining. <br>Secondary infertility is often unexpected. When you already have a child, facing new challenges in conceiving again can bring confusion and emotional strain. But with the right fertility care, the path to parenthood can open again.

- Birla Fertility & IVF, Gurgaon , (Dr. Prachi Benara & Dr. Rashmika Nanda)

Case Snapshot

Patient AgeMid–late 30s

Challenges Secondary infertility, uterine adhesions, thin endometrium, hydrosalpinx, hypothyroidism, male factor infertility

OutcomeSuccessful pregnancy after 10 years

TreatmentSurgical correction, PRP therapy, IVF with FET

Timeline8 months

Journey Timeline

1. Complex Challenges

2. Personalised Plans

3. Safe Retireval & Transfer

4. Guided Transfer

5. Successful Pregnancy

The Barriers They Faced

Severe Uterine Adhesions

Reduced cavity space and making implantation difficult

Thin, Poorly Vascularised Endometrium

Lowered the chances of embryo attachment

Bilateral Hydrosalpinx

Blocked fallopian tubes interfering with implantation

Hormonal Imbalance (Hypothyroidism)

Disrupted natural reproductive processes

Male Factor Infertility

Poor sperm motility and abnormal morphology

Failed IVF Attempts in the Past

Added emotional and psychological distress

Doctor's Quote

“The key was to tailor every aspect of care to this patient's unique needs, balancing safety, comfort, and clinical effectiveness.”

— Dr. Deepika Mishra

The Treatment Plan that made the Difference

Surgical Corrections

Adhesiolysis and metroplasty were performed to clear severe intrauterine adhesions and restore the normal structure of the uterine cavity. Additionally, tubal clipping was performed to block damaged tubes, thereby preventing hydrosalpinx fluid from flowing back into the uterus.

Medical Optimisation

Thyroid regulation was achieved with the help of oral medication, which helped balance hormone levels and support overall reproductive health. PRP Therapy was used to improve endometrial thickness and vascularisation, enhancing uterine receptivity for implantation.

IVF Protocols

Controlled ovarian stimulation was carried out using an antagonist protocol tailored to the patient’s ovarian reserve. This was followed by oocyte retrieval, during which 10 eggs were collected, with 8 maturing successfully. From these, two high-quality Day-5 blastocysts were developed.

Embryo Transfer

Frozen Embryo Transfer (FET) was performed after preparing the endometrium with GnRH agonist. There was a single blastocyst transfer done, which ensured precision and maximised implantation chances

A Story of Parenthood Against the Odds

This case proves that secondary infertility is not the end of the road. With the right combination of surgical precision, regenerative therapies like PRP, tailored IVF protocols, and emotional support, even decade-long battles can turn into success stories.
At Birla Fertility & IVF, Varanasi, under the guidance of Dr. Deepika Mishra (Centre Head & Consultant), their story took a hopeful turn. Despite complex medical conditions and two failed IVF cycles elsewhere, the right diagnosis, personalised treatment, and continuous care made all the difference.
Their story is proof that with science, compassion, and persistence, parenthood can happen again even after a decade of waiting.

The Outcome

Positive β-hCG: 4,485 mIU/mL confirmed conception and a successful pregnancy.

After a decade of waiting, the couple finally found joy again, holding on to hope, science, and care that never gave up on them.